pI: 9.7511 |
Length (AA): 179 |
MW (Da): 20606 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 175 | 1sqw (A) | 1 | 176 | 54.00 | 0 | 1 | 1.70585 | -0.96 |
94 | 161 | 2aus (C) | 251 | 318 | 24.00 | 0.000095 | 0.96 | 0.811988 | -1.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127869)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G15770 | RNA binding protein |
Babesia bovis | BBOV_II001600 | 60S ribosome subunit biogenesis protein NIP7, putative |
Brugia malayi | Bm1_35975 | 60S ribosome subunit biogenesis protein NIP7 |
Candida albicans | CaO19.3478 | similar to S. cerevisiae NIP7 (YPL211W) nucleolar protein required for 60S ribosome subunit biogenesis |
Candida albicans | CaO19.10982 | similar to S. cerevisiae NIP7 (YPL211W) nucleolar protein required for 60S ribosome subunit biogenesis |
Caenorhabditis elegans | CELE_C43E11.9 | Protein C43E11.9 |
Cryptosporidium hominis | Chro.40084 | hypothetical protein |
Cryptosporidium parvum | cgd4_660 | Nip7 like PUA domain containing protein involved in ribosomal biogenesis |
Dictyostelium discoideum | DDB_G0295477 | 60S ribosome subunit biogenesis protein |
Drosophila melanogaster | Dmel_CG7006 | CG7006 gene product from transcript CG7006-RA |
Echinococcus granulosus | EgrG_000827000 | 60s ribosome subunit biogenesis protein nip7 |
Entamoeba histolytica | EHI_017890 | 60S ribosome subunit biogenesis protein NIP7, putative |
Entamoeba histolytica | EHI_191530 | 60S ribosome subunit biogenesis protein NIP7, putative |
Entamoeba histolytica | EHI_031350 | 60S ribosome subunit biogenesis protein NIP7, putative |
Entamoeba histolytica | EHI_135590 | 60S ribosome subunit biogenesis protein NIP7, putative |
Echinococcus multilocularis | EmuJ_000827000 | 60s ribosome subunit biogenesis protein nip7 |
Giardia lamblia | GL50803_6177 | Ribosome subunit biogenesis protein NIP7 |
Homo sapiens | ENSG00000132603 | NIP7, nucleolar pre-rRNA processing protein |
Leishmania braziliensis | LbrM.33.1620 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_331430.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.33.1430 | hypothetical protein, conserved |
Leishmania major | LmjF.33.1350 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.32.1350 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_03649 | 60S ribosome subunit biogenesis protein NIP7 |
Mus musculus | ENSMUSG00000031917 | nuclear import 7 homolog (S. cerevisiae) |
Neospora caninum | NCLIV_035580 | 60S ribosome subunit biogenesis protein NIP7, putative |
Oryza sativa | 4344241 | Os07g0670600 |
Onchocerca volvulus | OVOC575 | 60S ribosome subunit biogenesis protein NIP7 homolog |
Plasmodium berghei | PBANKA_1330100 | 60S ribosome subunit biogenesis protein NIP7, putative |
Plasmodium falciparum | PF3D7_1466700 | 60S ribosome subunit biogenesis protein NIP7, putative |
Plasmodium knowlesi | PKNH_1214800 | 60S ribosome subunit biogenesis protein NIP7, putative |
Saccharomyces cerevisiae | YPL211W | Nip7p |
Schistosoma japonicum | Sjp_0050560 | ko:K07565 60S ribosome subunit biogenesis protein NIP7, putative |
Schistosoma mansoni | Smp_021760 | 60S ribosome subunit biogenesis protein |
Schmidtea mediterranea | mk4.002133.02 | |
Schmidtea mediterranea | mk4.005927.00 | 60S ribosome subunit biogenesis protein NIP7 homolog |
Trypanosoma brucei gambiense | Tbg972.10.14440 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.11990 | 60S ribosome subunit biogenesis protein NIP7, putative |
Trypanosoma congolense | TcIL3000_10_10190 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.510123.60 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511837.20 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_271280 | 60S ribosome subunit biogenesis protein NIP7, putative |
Theileria parva | TP04_0430 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_066780 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.11990 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.11990 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.11990 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.11990 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C43E11.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C43E11.9 | Caenorhabditis elegans | slow growth | wormbase |
YPL211W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_271280 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.